固溶处理对2205双相不锈钢组织及钝化膜特性的影响

用不同温度对2205双相不锈钢进行固溶处理,利用定量金相法及硬度法、电化学极化试验、电化学阻抗谱试验的方法研究固溶温度与2205双相不锈钢微观组织和钝化膜特性之间的关系。结果表明,当固溶温度为950 ℃时,有σ相存在,分布于铁素体/奥氏体晶界,当固溶温度为1000 ℃时,σ相消失,铁素体相比例随固溶温度的升高而升高,奥氏体相比例则呈相反规律;电化学试验和阻抗谱试验结果显示,材料在950 ℃时钝化膜稳定性和耐蚀性能最差,在1050 ℃时钝化膜稳定性和耐蚀性能最好。     

The Critical Role of Passive Permeability in Designing Successful Drugs

Passive permeability is a key property in drug disposition and delivery. It is critical for gastrointestinal absorption, brain penetration, renal reabsorption, defining clearance mechanisms and drug-drug interactions. Passive diffusion rate is translatable across tissues and animal species, while the extent of absorption is dependent on drug properties, as well as in vivo physiology/pathophysiology. Design principles have been developed to guide medicinal chemistry to enhance absorption, which combine the balance of aqueous solubility, permeability and the sometimes unfavorable compound characteristic demanded by the target. Permeability assays have been implemented that enable rapid development of structure-permeability relationships for absorption improvement. Future advances in assay development to reduce nonspecific binding and improve mass balance will enable more accurately measurement of passive permeability. Design principles that integrate potency, selectivity, passive permeability and other ADMET properties facilitate rapid advancement of successful drug candidates to patients.     

Data erasure in Fabry–Perot Diode Lasers: effects of facet reflectivity

ABSTRACT

In this study, the effects of facet reflectivity on the data erasure ability of injection-locked Fabry Perot Laser Diode (FPLD), based on a remodulation method in wavelength division multiplexed passive optical network (WDM PON), were investigated. For this purpose, the feasible front facet reflectivity of FPLD was determined as between 0.2% and 7%, depending on the specified injected power interval. Firstly, the system carried out analysis without applying data at the user end to comprehensively demonstrate how much downstream data was completely erased in FPLD. Then, 2.5 Gb/s of non-return-to-zero (NRZ) data was applied and the results compared with the erased downstream signal without data. The results show that upstream transmission improved with an increase in facet reflectivity between 0.2% and 7%.     

慢刀伺服车削刀具半径定向补偿的分段逼近求解

复杂曲面的慢刀伺服车削加工过程中，采用刀具法向补偿算法会在各个直线轴产生补偿量，加工法向矢量突变的曲面时，这种算法并非最优，将补偿量只应用于负载较低的直线轴却是更优的选择。提出一种基于线段逼近的刀具半径定向补偿数值求解算法来求解定向刀位点，通过半径细分的策略使法向误差收敛。算法实例验证及与相关算法的对比结果显示，该算法适用于点云构成的曲面或分段曲面的刀具半径补偿。     

Pleiotropic Effects of Sodium-Glucose Cotransporter-2 Inhibitors: Renoprotective Mechanisms beyond Glycemic Control

Diabetes mellitus is a major cause of chronic kidney disease and end-stage renal disease. However, the management of chronic kidney disease, particularly diabetes, requires vast improvements. Recently, sodium-glucose cotransporter-2 (SGLT2) inhibitors, originally developed for the treatment of diabetes, have been shown to protect against kidney injury via glycemic control, as well as various other mechanisms, including blood pressure and hemodynamic regulation, protection from lipotoxicity, and uric acid control. As such, regulation of these mechanisms is recommended as an effective multidisciplinary approach for the treatment of diabetic patients with kidney disease. Thus, SGLT2 inhibitors are expected to become key drugs for treating diabetic kidney disease. This review summarizes the recent clinical evidence pertaining to SGLT2 inhibitors as well as the mechanisms underlying their renoprotective effects. Hence, the information contained herein will advance the current understanding regarding the pleiotropic effects of SGLT2 inhibitors, while promoting future research in the field.     

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers,Signaling Pathways and miRNAome

Colorectal cancer (CRC) is a leading cause of cancer death worldwide, and about 20% is metastatic at diagnosis and untreatable. Increasing evidence suggests that the heterogeneous nature of CRC is related to colorectal cancer stem cells (CCSCs), a small cells population with stemness behaviors and responsible for tumor progression, recurrence, and therapy resistance. Growing knowledge of stem cells (SCs) biology has rapidly improved uncovering the molecular mechanisms and possible crosstalk/feedback loops between signaling pathways that directly influence intestinal homeostasis and tumorigenesis. The generation of CCSCs is probably connected to genetic changes in members of signaling pathways, which control self-renewal and pluripotency in SCs and then establish function and phenotype of CCSCs. Particularly, various deregulated CCSC-related miRNAs have been reported to modulate stemness features, controlling CCSCs functions such as regulation of cell cycle genes expression, epithelial-mesenchymal transition, metastasization, and drug-resistance mechanisms. Primarily, CCSC-related miRNAs work by regulating mainly signal pathways known to be involved in CCSCs biology. This review intends to summarize the epigenetic findings linked to miRNAome in the maintenance and regulation of CCSCs, including their relationships with different signaling pathways, which should help to identify specific diagnostic, prognostic, and predictive biomarkers for CRC, but also develop innovative CCSCs-targeted therapies.     

Effects of timing of formative feedback in computer-assisted learning environments

This study examines the effects of timing of corrective formative feedback on processing text information on question-answering. Undergraduate students read an expository text and answered questions in two attempts. Students were randomly assigned to a no feedback, immediate feedback and delayed feedback conditions. Students in the feedback conditions received feedback on the correctness of their answer after the first attempt and were informed about the right answer after the second attempt. Students were prompted to restudy the text after failing in their first attempt. However, students in the no feedback condition were just prompted to search the text. All students were tested on question-answering, corrective probability and a post-test cued-recall test. Results showed that: (a) feedback reduced the initial time reading the text; (b) feedback increased performance on question answering and cued-recall; (c) delayed feedback produced no advantages over immediate feedback. Theoretical and practical implications of these results are discussed.     

基于ＰＩＤ控制算法的直流微网容错控制方法研究

构建直流微网容错控制对象模型，调节直流微电网的输出回路参数；以输出功率、直流微网的 参考电压、弱电网下系统惯性响应特征等为约束参量，构建直流微网容错控制目标函数，在不同电网强度下 进行直流微网容错控制的参数自整定性调节，采用无功环比例积分控制方法进行直流微网容错寻优分析， 建立模糊 ＰＩＤ控制模型，采用变结构的模糊 ＰＩＤ控制方法进行直流微网容错控制过程中的自适应加权学习 和误差反馈调节，实现直流微网容错控制改进设计。仿真结果表明，采用该方法进行直流微网控制的容错 性能较好，输出稳定性较强，具有较好的直流微网输出增益。     

Vibration suppression for monopile and spar‐buoy offshore wind turbines using the structure‐immittance approach

Offshore wind turbines have the potential to capture the high‐quality wind resource. However, the significant wind and wave excitations may result in excessive vibrations and decreased reliability. To reduce vibrations, passive structural control devices, such as the tuned mass damper (TMD), have been used. To further enhance the vibration suppression capability, inerter‐based absorbers (IBAs) have been studied using the structure‐based approach, that is, proposing specific stiffness‐damping‐inertance elements layouts for investigation. Such an approach has a critical limitation of being only able to cover specific IBA layouts, leaving numerous beneficial configurations not identified. This paper adopts the newly introduced structure‐immittance approach, which is able to cover all network layout possibilities with a predetermined number of elements. Linear monopile and spar‐buoy turbine models are first established for optimisation. Results show that the performance improvements can be up to 6.5% and 7.3% with four and six elements, respectively, compared with the TMD. Moreover, a complete set of beneficial IBA layouts with explicit element types and numbers have been obtained, which is essential for next‐step real‐life applications. In order to verify the effectiveness of the identified absorbers with OpenFAST, an approach has been established to integrate any IBA transfer functions. It has been shown that the performance benefits preserve under both the fatigue limit state (FLS) and the ultimate limit state (ULS). Furthermore, results show that the mass component of the optimum IBAs can be reduced by up to 25.1% (7,486 kg) to achieve the same performance as the TMD.